Cancer Gene Therapy

Transient Prolactin Expression Enhances Antigen-Specific Responses

Published in Cancer Weekly, July 25th, 2000

The transient expression of human prolactin (hPRL) by adenoviral vectors enhances antigen-specific cytotoxic T lymphocytes (CTL) and natural killer (NK) responses in a murine cancer model, researchers in the United States reported.

"Bolus injection of mice with prolactin (PRL), a lactogenic hormone produced by the anterior pituitary, has been shown to upregulate the function of cells of the immune system, including B, T, and NK cells," reported B.F. Kavanagh and colleagues from Genzyme Corporation, Massachusetts. "In order to determine the effect of continuous exposure of the immune system to PRL, C57BL/6 mice were injected intravenously with a replication deficient...

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Source: Cancer Weekly (2000-07-25)

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