Published in Cancer Weekly, August 1st, 2000
"Adenovirus-p53-mediated apoptosis has been extensively evaluated in animal xenografts derived from human epithelial tumors and recently began testing in Phase I clinical trials, but has not been evaluated for lymphoid malignancies," stated F. Turturro and colleagues, John Stoddard Cancer Center, Iowa. "Cell lines derived from anaplastic large cell lymphoma (ALCL) carrying the t(2;5) translocation are efficiently transduced by adenoviral vector expressing p53 and undergo apoptosis. To test the in vivo efficiency of adenovirus-mediated-p53 expression and...
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