Cancer Gene Therapy
p53 Gene Transfer Inhibits p53-Mutated Human Melanoma Cells
Published in Cancer Weekly, August 1st, 2000
"The tumor suppressor gene p53 has inhibitory effects on cell growth and angiogenesis and induces apoptosis when overexpressed in melanoma and in a variety of tumor cells by adenovirus-mediated gene transfer," stated E. Toschi and colleagues, Institute Ricovero & Cura Carattere Sciences, Italy. "The invasive ability of tumor cells, facilitating local infiltration and metastasis, is related to matrix metalloproteinase levels. In melanoma, matrix metalloproteinase-2 and matrix metalloproteinase-9 have a prominent role in this process.
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Source: Cancer Weekly (2000-08-01)
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