Gliomas

Suicide Gene Therapy/Cytokine Vaccine Effective Against Brain Tumors

Published in Cancer Weekly, October 10th, 2000

Brain tumors appear to be sensitive to suicide gene therapy approaches.

"The aim of our experiments is to develop new therapeutical approaches for the treatment of brain tumors," stated Drs. Szilvia Desaknai and Geza Safrany from the National Research Institute for Radiobiology and Radiogygenie, Budapest, Hungary. "Glioma cells are transfected with adenovirus vectors coding for genes that sensitize cells to chemotherapeutic and antiviral agents. Such genes are the uracil phosphoribosyltransferase (UPRT) and thymidine kinase (TK) genes."

Desaknai and Safrany presented data from their study at the 14th European Immunology Meeting, held September...

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Source: Cancer Weekly (2000-10-10)

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