Colorectal Cancer
Mutations in Newly Discovered Gene Result in Defective Mismatch Repair
Published in Cancer Weekly, October 24th, 2000
This gene belongs to an important cell pathway that contains several other genes whose mutations have also been linked to colorectal or other cancers.
The study, published in the October 1, 2000, issue of Nature Genetics, demonstrates that mutations in the AXIN2 gene cause colorectal cancer by elevating the level of Beta-catenin, a protein known to be associated with the development of colorectal cancer.
"It has been known for a while that mutations in Adenomatous Polyposis Coli...
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Source: Cancer Weekly (2000-10-24)
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