Carcinogenesis
TP73 May Be a Tumor-Suppressor Gene
Published in Cancer Weekly, December 19th, 2000
The tumor suppressor protein p53 is one of the best characterized proteins in the cell, in part, because the gene encoding it (TP53) is mutated in nearly 50% of all human tumors. For years, p53 was believed to be in a class of its own. The discovery of p63 and p73, which closely resemble p53, raised the possibility that they, too, might be involved in suppressing the formation of tumors. But numerous investigations of p73 failed to unearth mutation of its gene (TP73) in cancers.
Overexpression of TP73, can, however, trigger programmed cell death (apoptosis) in a similar manner to overexpression of TP53, leading some to speculate that perhaps some of the functions...
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Source: Cancer Weekly (2000-12-19)
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