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Diagnostics

Gene Identification More Reliable for Detecting Micrometastasis in Lymph Nodes

Published in Cancer Weekly, January 30th, 2001

Though laboratory testing for markers such as cytokeratin are used in the analysis of tumors and tissues samples where metastasis is suspected, those tests are not always sensitive enough to distinguish cellular identifiers that occur in both normal and cancerous cells.

A new study reported in Cancer Research proposes that testing with a gene amplification method is a better way to identify micrometastasis, particularly within the lymph nodes of non-small cell lung cancer patients.

The method referred to by authors of the new study is called mutant allele-specific amplification (MASA). "MASA can detect DNAs derived from cancer cells itself,...

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