Leukemia

Vincristine Selectively Targets Malignant Cells for Apoptosis

Published in Cancer Weekly, February 13th, 2001

- by Michael Greer, staff medical writer -- Hematologists in Finland have shown that the antitubulin alkaloid vincristine selectively attacks malignant cells in patients with some forms of leukemia.

J.A. Vilpo and colleagues at Tampere University conducted a study to measure the "cytotoxicity of vincristine in vitro...in B chronic lymphocytic leukemia (CLL) cells and in normal peripheral blood mononuclear cells." The results of their research were published in the European Journal of Haematology.

They found that vincristine was roughly 25 times more likely to attack leukemic cells than normal monocytes. Sensitivity to the alkaloid was...

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Source: Cancer Weekly (2001-02-13)

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