Prostate Cancer

Changes in Growth Factors and Receptors Accompany Pre-Cancerous Lesions in Men

Published in Cancer Weekly, February 13th, 2001

- Sonia Nichols, staff medical writer -- A paracrine process that drives transforming growth factor (TGF) beta and its receptors is probably responsible for prostatic intraepithelial neoplasia, according to a report in Prostate.

These lesions, authors of the new study say, are believed to be the precursors to the development of prostate cancer in men, and are located adjacent to cells that express high levels of TGF-beta 1 and several of its receptors (TGF-beta RI, RII).

Y.C. Wong and associates at the University of Hong Kong used male noble rats to study normal tissues, prostatic intraepithelial neoplasia (PIN) lesions, and adjacent stromal...

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Source: Cancer Weekly (2001-02-13)

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