Prostate Cancer

Endogenous Enzyme Prevents Disease-Related Angiogenesis and Metastasis

Published in Cancer Weekly, February 13th, 2001

- Sonia Nichols, staff medical writer -- Surprising research shows that prostate cancer cells produce enzymes that prevent angiogenesis and the spread of cancer cells to other areas of the body.

The enzymes, called cathepsin D and procathepsin D, were identified in liquid growth media in which human prostate cancer cells had grown in the presence of plasminogen. Plasminogen is the parent compound of plasmin, a blood component that facilitates the disruption of blood clots.

Researchers say these compounds, via enzymatic reactions, work to generate angiostatic peptides from plasminogen. According to the investigators, angiostatin is an important...

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Source: Cancer Weekly (2001-02-13)

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