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Cancer Genetics

Penchant for Developing Drug Resistance is Result of Chromosome Reassortment

Published in Cancer Weekly, February 13th, 2001

A heretical theory about the origins of cancer could explain a longstanding medical mystery: why cancers often become resistant to the drugs used to treat them.

The controversial theory, if correct, also suggests a possible way to treat cancer to restore its sensitivity to drugs.

The theory, espoused by Peter Duesberg, University of California, Berkeley, disputes the common assumption that cancer results from a series of genetic mutations that kick a cell into uncontrolled growth.

Instead, Duesberg argues, cancer results from a wrench thrown into the machinery - the spindle apparatus - controlling chromosome splitting when a cell...

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