Cancer Vaccines
Growth-Factor-Based Vaccine Abrogates Angiogenesis and Tumor Formation
Published in Cancer Weekly, February 27th, 2001
"Basic fibroblast growth factor (FGF-2) is an important stimulator of angiogenesis that has been implicated in neoplastic progression," wrote S.M. Plum and colleagues of EntreMed Inc., Rockville, Maryland. "Attempts to neutralize or modulate FGF-2 have met with some success in controlling neovascularity and tumor growth."
"In the present study, two peptides, one corresponding to the heparin binding domain and the other to the receptor binding domain of FGF-2, exerted dose-dependent inhibition of...
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Source: Cancer Weekly (2001-02-27)
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