Published in Cancer Weekly, April 3rd, 2001
When considering gene therapy for the treatment of cancers, it is desirable to restrict expression of therapeutic genes to relevant tumor cells. M. Miyauchi et al. used a midkine promoter to express herpes simplex virus-thimidine kinase (HSV-TK) in midkine overexpressing tumor cells.
"Midkine (MK), a growth/differentiation factor, is expressed predominantly in various types of human tumors, whereas its expression in adult normal tissues is highly...
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