Cancer Gene Therapy

Midkine Promoter May Facilitate Therapy In Midkine-Overexpressing Tumors

Published in Cancer Weekly, April 3rd, 2001

by Deborah W. Heinrich, staff medical writer - Researchers in Japan preferentially expressed herpes simplex virus-thymadine kinase in human carcinoma cells, rendering them susceptible to gancyclovir.

When considering gene therapy for the treatment of cancers, it is desirable to restrict expression of therapeutic genes to relevant tumor cells. M. Miyauchi et al. used a midkine promoter to express herpes simplex virus-thimidine kinase (HSV-TK) in midkine overexpressing tumor cells.

"Midkine (MK), a growth/differentiation factor, is expressed predominantly in various types of human tumors, whereas its expression in adult normal tissues is highly...

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Source: Cancer Weekly (2001-04-03)

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