Hepatocellular Carcinoma

Simultaneous Adenoviral Vector Infection Induces Tissue-Specific Gene Expression

Published in Cancer Weekly, April 10th, 2001

by Deborah W. Heinrich, staff medical writer - Researchers at Kanazawa University in Japan used the simultaneous infection of two recombinant adenoviral vectors to induce tissue-specific gene expression in disseminated hepatocellular carcinoma in a mouse model.

(alpha)-fetoprotein is expressed preferentially in hepatic cells. Gene therapy using the (alpha)-fetoprotein promoter exhibits tissue specificity; however, the promoter does not boast strong transcriptional activity.

To overcome this obstacle, Y. Sakai and colleagues created two recombinant adenoviral vectors: one with the cre gene under control of the (alpha)-fetoprotein promoter and...

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Source: Cancer Weekly (2001-04-10)

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