Colon Cancer
Antisense uPAR Expression Suppresses Tumor Metastasis
Published in Cancer Weekly, May 8th, 2001
Y. Wang and colleagues created antisense uPAR-expressing vectors encompassing either the 3' or 5' ends of uPAR mRNA. Vectors were transfected into HCT116, which is a colon cancer cell line with a high metastatic potential. After confirming transfection with DNA hybridization, clones were evaluated for receptor bound endogenous uPA activities and for extracellular matrix degradation.
In the April 2001 issue of...
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Source: Cancer Weekly (2001-05-08)
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