Colon Cancer

Antisense Amyloid Beta Protein Precursor Suppresses Tumor Growth

Published in Cancer Weekly, May 8th, 2001

by Deborah W. Heinrich, staff medical writer - Researchers at Miyazaki Medical College in Japan report that the proliferative potential and colony-forming efficiency of human colon carcinoma cell line SW837 was suppressed by antisense amyloid beta protein precursor (APP) oligonucleotides.

Although a membrane-bound form of AAP is expressed by many cell types, J.Y. Meng and colleagues previously reported that a soluble form of the protein is secreted by human colon carcinoma cells. The secreted form inhibited serine proteinase most likely via a Kunitz-type inhibitor domain, they suggested.

In their current study, Meng et al. created a vector...

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Source: Cancer Weekly (2001-05-08)

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