Tumorigenesis

Miscommunication Between Protein And Attachment Signal Can Induce Cancer-Cell Growth

Published in Cancer Weekly, May 8th, 2001

Normal cells need two signals in order to divide: a growth factor protein, and an indication that the cells are attached to the "correct" surface.

Researchers have now discovered how these two signals are integrated. Loss of control over the attachment signal may allow cancer cells to grow even when they are not in the correct part of the body.

Andrew Aplin, of the University of North Carolina at Chapel Hill, and colleagues reported in the April 16, 2001, issue of the Journal of Cell Biology that growth factors turn on a set of proteins called extracellular-regulated kinases (ERKs).

To do their job, active ERKs have...

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Source: Cancer Weekly (2001-05-08)

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