Published in Cancer Weekly, May 15th, 2001
Several studies have shown the endothelial cell-specific receptors Tie 1 and Tie 2 bind with vascular remodeling molecules called angiopoietins. Now, researchers in Italy suggest angiopoietin-1 is a significant modulator of angiogenesis in glioblastomas.
Using immunohistochemical analysis and in situ hybridization, Enrica Audero and research colleagues studied several cell lines for the expression of angiopoietins 1 (Ang1) and 2 (Ang2) in astrocytomas and glioblastomas.
"Our observations of...
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