Published in Cancer Weekly, May 15th, 2001
I. Ganly and colleagues noted that the ONYX-015 adenovirus induced lysis of cells with p53 mutations. In this study, they used ONYX-015 to infect human ovarian tumor cell lines with known p53 mutations and chemoresistance and reported their results in Gene Therapy.
The parent cell line, A2780, is chemosensitive to cisplatin and expresses wild-type p53. The mutant p53 derivative, A2780/cp70 is cisplatin resistant. Ganly and coworkers...
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