Acute Myeloid Leukemia

Cytogenetics Affects Prognostic Value Of Bcl Expression

Published in Cancer Weekly, May 29th, 2001

by Michael Greer, senior medical writer - Bcl gene expression can provide valuable information for optimizing acute myeloid leukemia (AML) treatment, but this prognostic value often depends on cytogenetic and other factors, researchers in Germany argue.

"So far expression studies of apoptosis-regulating genes on [AML] have mainly focused on Bcl-2 itself," according to Markus Schaich and colleagues. " ...most of them have not included other factors involved in drug resistance or apoptosis as parameters determining response to chemotherapy, disease progression and survival."

After multivariate analysis including other risk factors, Schaich and...

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Source: Cancer Weekly (2001-05-29)

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