Non-Small Cell Lung Cancer

Researchers Identify Novel Gene Target For Cancer Therapy

Published in Cancer Weekly, June 5th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - With limited therapies for such cancers as non-small cell lung carcinoma, researchers in France have turned their attention to developing a novel mRNA transcript that arrests tumor cell growth.

D. Carbonelle and colleagues at ISOmer marine pharmacology lab in Nantes, France looked for clues in the genetics of an NSCLC cell line after treatment with methyl 4-methoxy-3-(3-methyl-2-butenoyl) benzoate (VT1), a chemical that induces cell cycle arrest at the G1 phase. The researchers used "differential display" to examine gene expression modifications after VT1 administration. Results from this assay would provide an idea...

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Source: Cancer Weekly (2001-06-05)

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