Breast Cancer

Major Hurdle In The Development Of An Animal Model Of Hereditary Disease Has Been Overcome

Published in Cancer Weekly, June 5th, 2001

Breast cancer is the most prevalent type of cancer in women, with 192,000 new cases expected this year in the U.S. alone. Despite extensive research efforts, scientists have been unable develop a mouse model of hereditary breast cancer. Until now.

As published in the May 15, 2001, issue of Genes & Development, a collaboration of researchers from Columbia University and the Dana-Farber Cancer Institute have generated a mouse strain with an inherited mutation in Brca1.

The breast and ovarian cancer susceptibility gene, Brca1, is the most commonly detected genetic mutation in familial breast and ovarian cancer. Although structural analysis...

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Source: Cancer Weekly (2001-06-05)

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