Hepatoma

Novel Tetracycline Transactivators Allow Nontoxic Transgene Regulation

Published in Cancer Weekly, June 12th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Gastroenterologists at the Medical School of Hannover, Germany have created novel, nontoxic tetracycline-responsive transactivators for the tight regulation of transgene expression in liver gene therapy.

The Tet System (TS) is a classic one used for tight regulation of gene expression in mammalian cells. In this system, transgene expression is regulated by the human cytomegalovirus immediate-early 1 gene promoter (HCMV1E) with tetracycline-repressible transactivator (tTA) operator sequences. This promoter is activated by tTA, which is a hybrid between the tetracycline repressor and the HSV transcriptional activator...

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Source: Cancer Weekly (2001-06-12)

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