Colorectal Cancer

Non-Steroidal Anti-Inflammatory Drugs Block Calcium, Cell Proliferation

Published in Cancer Weekly, June 12th, 2001

by Sonia Nichols, senior medical writer - New research shows store-operated calcium blockage may be the mechanism by which non-steroidal anti-inflammatory drugs (NSAIDs) prevent cellular growth in colorectal cancers.

"NSAIDs inhibit proliferation and angiogenesis in colorectal cancer," the authors of an Austrian multicenter study said in the International Journal of Cancer. However, the mechanism by which these drugs inhibit cellular proliferation in colorectal cancer has not been clarified until now.

"We examined a possible involvement of store-operated calcium (SOC) entry in human colon carcinoma cells (HRT-18), which require calcium for...

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Source: Cancer Weekly (2001-06-12)

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