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Glioma

COX-2 Cited As Prognostic Marker In Aggressive Tumors

Published in Cancer Weekly, June 26th, 2001

by Sonia Nichols, senior medical writer - COX-2, an enzyme linked to angiogenesis, has been pronounced a prognostic marker in human gliomas by neurosurgeons.

The researchers, who work at the University of Texas M.D. Anderson Cancer Center, report elevated levels of the inducible enzyme cyclooxygenase (COX)-2 are common in aggressive forms of glioma, and patients with tumors that express higher levels of the enzyme encounter poorer survival rates.

"We examined COX-2 expression by immunohistochemistry in tumor specimens from 66 patients with low- and high-grade astrocytomas and correlated the percentage of COX-2 expression with patient survival," said...

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