Insulinoma

Rat Insulin Promoter Confers Beta-Cell-Specific Transgene Expression

Published in Cancer Weekly, June 26th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Using rat insulin promoter expression of the suicide gene thymidine kinase, researchers in the U.S. maintained blood sugar levels and avoided hypoglycemic death in a SCID mouse insulinoma model.

For the treatment of insulin-secreting islet cell tumors, T.A. Tirone and colleagues at Baylor College of Medicine in Houston, Texas, decided that an insulin promoter would be a logical choice for tissue-specific expression of therapeutic genes. In a current study published in the May 2001 issue of Annals of Surgery, they reported creating constructs to assess the feasibility of a rat insulin promoter for...

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Source: Cancer Weekly (2001-06-26)

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