Retinoblastoma

Acetylation Of Tumor Suppressor Gene's Protein Controls Cell Proliferation

Published in Cancer Weekly, July 3rd, 2001

Mutations in the retinoblastoma gene lead to the development of tumors within the eye retina in young children. Approximately one child in every 15,000 to 30,000 births in the U.S. will develop a retinoblastoma. Most of these individuals are born with one mutant copy of the Retinoblastoma (Rb) gene, and develop the tumors when they acquire a second mutated copy.

Rb plays an important role in controlling cell proliferation within the eye retina, and other cells, but how the action of Rb is controlled is not understood. New work published in the July 2001 issue of Nature Cell Biology by Dr. Nicholas La Thangue, University of Glasgow, and colleagues has...

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Source: Cancer Weekly (2001-07-03)

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