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Laryngeal Cancer

p53/GM-CSF Therapy Stimulates Antitumor Immunity And Growth Inhibition

Published in Cancer Weekly, July 31st, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Human laryngeal cancer cells transfected with adenovirus-expressing p53 and granulocyte-macrophage colony-stimulating factor are growth arrested and exhibit enhanced immunogenicity.

Z.H. Qiu and colleagues at the Beijing Institute for Radiation Medicine in Beijing, combined two methods of treating laryngeal cancer in hopes of achieving additive antitumor effects. They constructed an adenovirus vector expressing both wild-type p53 and granulocyte-macrophage colony-stimulating factor (GM-CSF). The vector (Ad-p53/GM-CSF) was transfected into human laryngeal cancer cells, Hep-2, and the results were reported in Cancer...

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