Bladder Cancer

HSV-tk/GCV Inhibits Growth Of Chemically Induced Tumors In Mice

Published in Cancer Weekly, July 31st, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Researchers in Japan have inhibited growth of bladder tumors in mice with suicide gene therapy.

S. Akasaka and colleagues at Nippon Medical School, Tokyo, reported results from their attempts to treat bladder cancer in a mouse model. Tumors were induced in mice with BBN (N-butyl-N-(4-hydroxybutyl)nitrosamine). When examined histologically, they appeared quite similar to human bladder tumors, and they were shown to be transducible by adenovirus.

Akasaka and colleagues then constructed a herpes simplex virus thymidine kinase (HSV-tk)-expressing adenovirus vector and administered it to the bladders...

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Source: Cancer Weekly (2001-07-31)

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