Published in Cancer Weekly, July 31st, 2001
In order to maintain appropriate oxygenation, solid tumor growth is accompanied by angiogenesis. Research indicates that angiogenesis itself is stimulated by cell stress due to low oxygen levels and is mediated by factors such as vascular endothelial growth factor (VEGF). K. Ozawa and colleagues at Kanazawa University in Ishikawa, Japan suggest that VEGF is regulated by endoplasmic reticulum (ER) chaperones. A 150-kDa ER oxygen-regulated protein (ORP150) coexpressed with VEGF in human...
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