Glioma

Oxygen-Regulated Protein Is A New Target For The Prevention Of Tumor Angiogenesis

Published in Cancer Weekly, July 31st, 2001

by Deborah W. Heinrich, PhD, staff medical writer - A recent study implicates oxygen-regulated protein 150 as a novel target for gene therapy in the prevention of tumor angiogenesis.

In order to maintain appropriate oxygenation, solid tumor growth is accompanied by angiogenesis. Research indicates that angiogenesis itself is stimulated by cell stress due to low oxygen levels and is mediated by factors such as vascular endothelial growth factor (VEGF). K. Ozawa and colleagues at Kanazawa University in Ishikawa, Japan suggest that VEGF is regulated by endoplasmic reticulum (ER) chaperones. A 150-kDa ER oxygen-regulated protein (ORP150) coexpressed with VEGF in human...

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Source: Cancer Weekly (2001-07-31)

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