Multiple Myeloma

Major T-Cell Molecule May Influence IL-8 Role In Bone Marrow Cancer

Published in Cancer Weekly, July 31st, 2001

by Sonia Nichols, senior medical writer - A major molecule on T cells that commonly modulates interleukin (IL)-2 transcription may also stimulate IL-8 production in patients with multiple myeloma.

The molecule, called CD28, regulates the function of a number of cytokines, and is usually found on CD4 T cells and a variety of cells in the plasma. U.S. researchers have generated evidence that this molecule may activate a promoter on IL-8, an angiogenesis cytokine, in myeloma cells.

According to Virginia Smith Shapiro and colleagues, University of Pennsylvania, CD28 uses a RE/AP composite element to activate IL-2 production.

Although...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Cancer Weekly

Source: Cancer Weekly (2001-07-31)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry