Published in Cancer Weekly, July 31st, 2001
The molecule, called CD28, regulates the function of a number of cytokines, and is usually found on CD4 T cells and a variety of cells in the plasma. U.S. researchers have generated evidence that this molecule may activate a promoter on IL-8, an angiogenesis cytokine, in myeloma cells.
According to Virginia Smith Shapiro and colleagues, University of Pennsylvania, CD28 uses a RE/AP composite element to activate IL-2 production.
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