Epidemiology

Toxin Exposure, Hepatitis B Are Primary Liver Cancer Factors In China

Published in Cancer Weekly, August 14th, 2001

by Sonia Nichols, senior medical writer - Although exposure to aflatoxin and infection with hepatitis B virus (HBV) are two major risk factors for primary liver cancer, or hepatocellular carcinoma (HCC), in China, the pair do not appear to have a synergistic effect on p53 genetic mutations, according to a new report.

Genetic mutations are often seen in liver cancer tumors removed from individuals in China, M.C. Stern and associates at the U.S. National Institutes of Health (NIH) said in Cancer Epidemiology, Biomarkers and Prevention.

"A G to T transversion at codon 249 of the p53 gene (249(ser)) is commonly found in HCCs from patients in...

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Source: Cancer Weekly (2001-08-14)

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