Liver Cancer

Viral Oncolysis Is Enhanced By Gene Therapy

Published in Cancer Weekly, September 11th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Combining the antineoplastic properties of herpes simplex virus 1 with suicide gene therapy may be the key to treating diffuse liver metastases, say Harvard researchers.

"Infection of tumor cells by herpes simplex virus 1 (HSV-1) results in cell destruction and production of progeny virion in a process referred to as viral oncolysis," explained H. Nakamura and colleagues, Harvard University, Massachusetts General Hospital, Boston, Massachusetts. They proposed that oncolysis may be enhanced with suicide gene therapy, but the trick would be to find a gene and prodrug combination that would not affect viral...

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Source: Cancer Weekly (2001-09-11)

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