Breast And Ovarian Cancer

E1A Therapy Used In Phase I Trial

Published in Cancer Weekly, September 11th, 2001

by Deborah W. Heinrich, PhD, staff medical writer - Researchers in Houston call for the start of Phase II trials after successful use of E1A gene therapy for breast and ovarian cancer.

In a recent study, published in the Journal of Clinical Oncology, G.N. Hortobagyi and colleagues in the Univeristy of Texas M.D. Anderson Cancer Center, Houston, reported results from a Phase I clinical trial using gene therapy to treat 18 patients with advanced breast and ovarian cancers. The liposome-complexed E1A gene from adenovirus was administered once weekly into the peritoneal or thoracic cavities of the participants. Transgene expression and tumor cell responses were...

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Source: Cancer Weekly (2001-09-11)

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