Prostate Cancer

DNA PSA Vaccine Safe And Immunogenic In Macaques

Published in Cancer Weekly, September 25th, 2001

by N.R. Saltmarsh, staff medical writer - A DNA vaccine expressing human prostate-specific antigen (PSA) shows promise in rhesus macaques, researchers in the United States have found.

J.J. Kim and colleagues at the University of Pennsylvania previously reported on the use of a DNA vaccine that encodes for human PSA to elicit host immune responses against cells producing PSA. Here, they examined immune responses and safety profiles in macaques immunized with DNA-based PSA vaccine.

"DNA immunization strategy delivers DNA constructs encoding for a specific immunogen into the host, who becomes the in vivo protein source for the production of antigen,"...

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Source: Cancer Weekly (2001-09-25)

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