Cancer Gene Therapy

Gene That Prevents Tumor Growth Also Carries Messages From Circadian Clock

Published in Cancer Weekly, October 9th, 2001

Scientists have long known that the gene Nf1 is so important to development that when it is missing the condition known as neurofibromatosis results, causing tumors and sometimes leading to cancer before the patient reaches adulthood.

Now researchers have discovered that the Nf1 gene serves a second major purpose, it is also necessary for circadian rhythm. The body can't maintain its rest-activity cycle without it.

"There have been a lot of anecdotal reports by physicians that many patients suffering from neurofibromatosis also suffer from sleep disturbances. But this is the first time someone has definitively linked Nf1 to the circadian system,"...

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Source: Cancer Weekly (2001-10-09)

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