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Chronic Lymphocytic Leukemia

Antioxidants protect malignant cells in vivo

Published in Cancer Weekly, March 19th, 2002

by Michael Greer, senior medical writer - Researchers in the United Kingdom may have provided an explanation for the curious survival patterns of some leukemia cells.

"Chronic lymphocytic leukemia (CLL) cells are long lived in vivo but undergo spontaneous apoptosis when cultured in vitro," explained Dr. Elizabeth C. Moran and colleagues at the Royal Liverpool University Hospital in Liverpool. "Intriguingly, CLL cells also appear to have a specific susceptibility to oxidative stress - a potent inducer of apoptosis."

Moran and coauthors identified a number of factors that protect CLL cells from oxidative stress in circulation and in tissues.

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