Molecular Biology

Built-in 'failsafe' device blocks abnormal growth of new blood vessels

Published in Cancer Weekly, May 7th, 2002

Some inhibitors of angiogenesis prevent new blood vessel growth by triggering a built-in "failsafe" device in vessel-forming endothelial cells that marks them for apoptosis, or programmed cell death, according to a study from the Feinberg School of Medicine at Northwestern University and Washington University at St. Louis.

By identifying the molecular mechanisms that control this failsafe device, it may be possible to design new antiangiogenic drugs or to improve already existing drugs to prevent abnormal blood vessel growth, said Olga Volpert, assistant professor of urology at the Feinberg School and lead author the study, which appeared in the April 2002 issue of the...

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Source: Cancer Weekly (2002-05-07)

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