Acute Myeloid Leukemia

Wilms tumor gene expression marks stem cell graft contamination

Published in Cancer Weekly, May 14th, 2002

by Michael Greer, senior medical writer - Acute myeloid leukemia (AML) cells express high levels of Wilms tumor gene 1 (WT1), which can be used to detect these cells in stem cell grafts, researchers say.

"High-dose chemotherapy with subsequent autologous stem cell transplantation is believed to be of therapeutic benefit in patients with acute myeloid leukemia (AML), especially when no allogeneic bone marrow donor is available," explained Dr. J. Siehl and colleagues at Benjamin Franklin University Hospital in Berlin, Germany. " One of the main risks is contamination of the stem cell preparations with leukemic blasts, which may account for a higher relapse rate compared...

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Source: Cancer Weekly (2002-05-14)

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