Hypoxia

Oxygen deprivation accounts for pathways leading to vascular invasion

Published in Cancer Weekly, June 18th, 2002

by Sonia Nichols, senior medical writer - Cell culture experiments have demonstrated that hypoxia leads to connective tissue growth factor production, facilitating matrix degradation, angiogenesis, and vascular invasion.

Scientists report connective tissue growth factor (CTGF) is just one of several known modulators of angiogenesis, or neovascularization. S. Kondo and colleagues at Okayama University Graduate School of Medicine and Dentistry of Okayama, Japan recently reported that hypoxia-induced CTGF can lead to a cascade of events culminating in vascular invasion.

In the researchers' study, they used human breast cancer cells (MDA231) and...

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Source: Cancer Weekly (2002-06-18)

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