Breast Cancer

Strategy of eliminating Stat5a might reduce breast cancer cell survival

Published in Cancer Weekly, July 9th, 2002

by Sonia Nichols, senior medical writer - Murine model experiments suggest Stat5a gene activation promotes breast cancer. Researchers now think that by decreasing the activity of this gene, breast cancer cells could be eliminated.

Stat gene activation is comparable in human and murine breast cancers, according to a report in the journal Oncogene. "Similar to human breast cancers, a proportion of mammary adenocarcinomas in the WAP-TAg transgenic mouse model demonstrate constitutive Stat5a/b and Stat3 activation," described S. Ren and coauthors, who work at the Lombardi Cancer Center of Georgetown University in Washington, DC.

When the...

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Source: Cancer Weekly (2002-07-09)

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