Cancer Therapy

Trojan horse drug duo destroys tumors' blood supply

Published in Cancer Weekly, July 9th, 2002

Researchers have demonstrated in mice that a new drug formed by linking a vascular endothelial growth factor to a toxin will target and destroy the blood vessels supplying a malignant tumor.

The work was done by scientists at the University of Texas (UT) M.D. Anderson Cancer Center in Houston and The University of Texas Southwestern Medical Center at Dallas.

Dr. Michael Rosenblum, professor of medicine at M.D. Anderson, said tests of VEGF121/rGelonin (VEGF/rGel) in mice demonstrated it could selectively destroy blood vessels supplying human solid tumors without harming the vasculature of normal tissue.

"This is like a 'Trojan...

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Source: Cancer Weekly (2002-07-09)

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