Ovarian Cancer

Similar pathways may be involved in hereditary and sporadic ovarian cancers

Published in Cancer Weekly, July 30th, 2002

New research suggests that BRCA1 and BRCA2 gene mutations lead to hereditary ovarian cancers through different pathways, but that these pathways may be similar to ones at work in sporadic ovarian cancers. These findings appear in the July 3, 2002, issue of the Journal of the National Cancer Institute.

BRCA1 and BRCA2 are tumor suppressor genes that play important roles in cellular functioning such as DNA damage repair. Mutations in these genes have been associated with 5-10% of epithelial ovarian cancers. Whether BRCA1 and BRCA2 mutations lead to cancer through similar or different pathways is unclear. A past study of BRCA1 and BRCA2-linked breast cancers...

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Source: Cancer Weekly (2002-07-30)

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