Breast Cancer Pathogenesis

Study identifies upregulated enzyme in invasive breast cancers

Published in Cancer Weekly, September 10th, 2002

by Sonia Bell-Nichols, senior medical writer - Upregulated expression of an extracellular enzyme seems be responsible for the invasiveness of breast cancers. Diminishing its activity at the molecular level could be one way of curbing breast cancer metastasis, researchers suggest.

In earlier studies, Dawn A. Kirschmann and colleagues at the Holden Comprehensive Cancer Center at The University of Iowa in Iowa City found that lysyl oxidase (LOX) expression, responsible for degrading the "glue" that holds cells together, is higher in breast cancers that are invasive than in breast cancers that are not.

A subsequent study has examined LOX at a molecular...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Cancer Weekly

Source: Cancer Weekly (2002-09-10)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry