Breast Cancer

Risk from susceptibility gene may be exaggerated in most studies

Published in Cancer Weekly, September 17th, 2002

An analysis of past studies on mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 suggests that estimates of penetrance (or the likelihood that mutation carriers will develop breast cancer during their lifetime) have been exaggerated.

This can happen because a woman's risk of developing breast cancer is likely to be associated not only with the specific genetic mutation but also with many other risk factors, concluded a study in the August 21, 2002, issue of the Journal of the National Cancer Institute.

Accurately estimating penetrance is important for genetic counseling because the estimates may influence decisions about...

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Source: Cancer Weekly (2002-09-17)

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