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Stem Cell Transplantation

Unrelated enriched grafts carry high risk, even with donor lymphocyte infusions

Published in Cancer Weekly, September 17th, 2002

by Michael Greer, senior medical writer - Enriched stem cell grafts from unrelated donors carry a high morbidity risk, even for patients treated with additional prophylactic procedures, researchers in Germany say.

Martin Bornhauser and colleagues at Carl Gustav Carus University in Dresden assessed the benefits and risks of unrelated, CD34-selected peripheral blood progenitor cell (PBPC) grafts for leukemia and lymphoma patients.

The researchers found that these grafts were associated with high rates of infection and other complications and that donor lymphocyte infusions (DLI) offers limited protection against these developments.

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