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Multiple Myeloma

Estrogen derivative defeats drug resistant cells in bone marrow cancer

Published in Cancer Weekly, October 1st, 2002

by Sonia Nichols, senior medical writer - The estrogen derivative 2-methoxyestradiol can override drug resistance in multiple myeloma.

The growth of multiple myeloma, a bone marrow cancer that mostly affects men, depends on angiogenesis and oncogenic activity. 2-Methoxyestradiol (2ME2) regulates cancer growth influences such as apoptosis and angiogenesis.

Researchers at the Dana-Farber Cancer Institute at Harvard Medical School in Boston, Massachusetts think 2ME2 may extend survival in multiple myeloma (MM) patients by enabling cancer cells to overcome resistance to standard therapies.

The Harvard team evaluated the effects of...

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