Cancer Growth

Lidocaine inhibits cancer cell invasion

Published in Cancer Weekly, October 15th, 2002

Researchers in Japan reported that in their studies, the commonly used anesthetic lidocaine inhibited invasion of cancer cells.

"Although the mechanism is unknown, infiltration anesthetics are believed to have membrane-stabilizing action," wrote T. Mammoto and colleagues, Osaka Medical Center for Cancer and Cardiovascular Disease.

"We report here that such a most commonly used anesthetic, lidocaine, effectively inhibited the invasive ability of human cancer (HT1080, HOS, and RPMI-7951) cells at concentrations used in surgical operations (5-20 mM)."

According to Mammoto and coauthors, "Ectodomain shedding of heparin-binding...

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Source: Cancer Weekly (2002-10-15)

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