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Acute Myeloid Leukemia

Levels of Expression of CD34 Epitope Classes Have Prognostic Value

Published in Cancer Weekly, October 22nd, 2002

"The various epitopes of the CD34 molecule have been classified according to their different sensitivities to enzymatic cleavage by neuraminidase, chymopapain and a glycoprotease from Pasteurella haemolytica. Although monoclonal antibodies have been developed that specifically identify these epitopes, few studies have evaluated the distribution and quantitative expression of such epitopes on leukemic blasts," researchers in France report.

In a prospective multicenter study, the scientists, led by M. Maynadie, "examined and quantified the expression of the three classes of CD34 on fresh leukemic blast cells from 300 cases of acute myeloid leukemia (AML). The...

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