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Cancer Vaccines

Cloned T9 cells protect against intracranial glioma tumors

Published in Cancer Weekly, October 22nd, 2002

by Maria G. Essig, MS, ELS, senior medical writer - Immunity against intracranial T9 gliomas was conferred by treatment of rats with live cloned T9-C2 glioma cells that expressed macrophage colony-stimulating factor (mM-CSF), according to a report by researchers from the U.S.

Yijun Chen and colleagues at the University of California-Irvine, and California State University and the Veterans Affairs Medical Center in Long Beach, found that control T9 glioma cells formed subcutaneous tumors in rats but cloned T9-C2 cells expressing mM-CSF or Bcl2 did not.

The mechanism of protection conferred by immunization using T9-C2 cells involved vacuolization of...

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